Database : HANSEN Search on : LINHAGEM CELULAR [Subject descriptor] References found : 12 [refine] Displaying: 1 .. 12   in format [Detailed]

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Id: 17550 Author: Dugue, Christophe; Perraut, Ronald; Youinou, Pierre; Renaudineau, Yves Title: Effects of anti-endothelial cell antibodies in leprosy and malaria ..- Source: s.l; s.n; Jan. 2004. 9 p. ilus, tab, graf. Abstract: As a result of damaging endothelial cells (ECs), Mycobacterium leprae triggers the production of antibodies (Abs). These anti-EC Abs (AECAs) can be divided into two types. The first type nonspecifically reacts with components of the cytosol (CY) and can be detected by enzyme-linked immunosorbent assay (ELISA). The second specifically reacts with the EC membrane (MB) and requires fluorescence-activated cell sorter (FACS) analysis to be detected. The presence of both types of AECAs was determined in 68 leprosy patients. The ELISA was positive for 35 of them but also for 30 of 34 malaria patients and 17 of 50 healthy African controls. However, whereas FACS analysis showed MB reactivity in only three malaria patients and four controls, this reactivity was found in 27 leprosy patients, more of those having the lepromatous than the tuberculoid form. Specificity for MB, which we failed to absorb by incubation with CY lysates, predominated over that for CY in leprosy, unlike malaria, where the EC reactivity was restricted to the CY. Western blot analysis and two-dimensional electrophoresis revealed that calreticulin, vimentin, tubulin, and heat shock protein 70 were targeted by AECAs from leprosy patients, but other proteins remained unidentified. These auto-Abs, but not those from malaria patients, did activate ECs, as indicated by the E-selectin and intercellular adhesion molecule 1 upregulation, and/or induced them into apoptosis, as documented by four different methods. Our findings suggest that, in some but not all leprosy patients, AECAs may play a role in pathogenesis. (AU). Descriptors: Auto-Anticorpos/*IM Auto-Antígenos/IM Linhagem Celular Citossol/IM Células Endoteliais/*IM/MI/PS ELISA Citometria de Fluxo Hanseníase/*IM/*PP Malária Falciparum/*IM/*PP Limits: HUMANO MASCULINO FEMININO ADOLESCENCIA ADULTO MEIA-IDADE SUPPORT, NON-U.S. GOV'T Location: BR191.1; 09329/s

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Id: 13944 Author: Bochud, Pierre-Yves; Hawn, Thomas R; Aderem, Alan Title: Cutting edge: a toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling ..- Source: s.l; s.n; 2003. 4 p. graf. Abstract: Toll-like receptors (TLRs) are key mediators of the innate immune response to microbial pathogens. We investigated the role of TLRs in the recognition of Mycobacterium leprae and the significance of TLR2Arg(677)Trp, a recently discovered human polymorphism that is associated with lepromatous leprosy. In mice, TNF-alpha production in response to M. leprae was essentially absent in TLR2-deficient macrophages. Similarly, human TLR2 mediated M. leprae-dependent activation of NF-kappaB in transfected Chinese hamster ovary and human embryonic kidney 293 cells, with enhancement of this signaling in the presence of CD14. In contrast, activation of NF-kappaB by human TLR2Arg(677)Trp was abolished in response to M. leprae and Mycobacterium tuberculosis. The impaired function of this TLR2 variant provides a molecular mechanism for the poor cellular immune response associated with lepromatous leprosy and may have important implications for understanding the pathogenesis of other mycobacterial infections. (AU). Descriptors: CELULAS CHO LINHAGEM CELULAR IMUNIDADE NATURAL/genet ARGININA/genet HANSENIASE VIRCHOWIANA/genet HANSENIASE VIRCHOWIANA/imunol HANSENIASE VIRCHOWIANA/microbiol GLICOPROTEINAS DE MEMBRANA/defic GLICOPROTEINAS DE MEMBRANA/genet GLICOPROTEINAS DE MEMBRANA/fisiol CAMUNDONGOS ENDOGÂMICOS C57BL CAMUNDONGOS KNOCKOUT MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM TUBERCULOSIS/imunol POLIMORFISMO DE UM UNICO NUCLEOTIDIO/imunol TRANSDUCAO DE SINAL/imunol TRIPTOFANO/genet RECEPTORES DA SUPERFICIE CELULAR/defic RECEPTORES DA SUPERFICIE CELULAR/genet RECEPTORES DA SUPERFICIE CELULAR/fisiol Limits: HUMANO ANIMAL HAMSTERS CAMUNDONGOS SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 09085/s

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Id: 13314 Author: Tung, K. S; Kim, B; Bjorvatn, B; Kronvall, G; McLaren, L. C; Williams, R. C Title: Discrepancy between Clq deviation and Raji cell tests in detection of circulating immune complexes in patients with leprosy ..- Source: s.l; s.n; aug. 1977. 6 p. ilus, tab, graf. Abstract: Samples of serum from 45 patients with different clinical forms of leprosy and from 17 patients with systemic lupus erythematosus were studied in parallel for circulating immune complexes with use of two different in vitro tests adjusted to the same degree of sensitivity. The Clq deviation test relied upon the reaction of the complement component Clq with immune complexes. The Raji cell test detected complement-fixed immune complexes that bound to the complement receptors on cultured, bone marrow-derived lymphocyte-like Raji cells. Thirty (67%) of 45 patients with leprosy showed immune complexes according to the Clq deviation test; however, only two (7%) of the 30 samples of sera with positive Clq test results were positive by the Raji cell test. In contrast, 54% of 13 samples of sera from patients with systemic lupus erythematosus positive by the Clq test were positive according to the Raji cell test. Since Clq is known to react with DNA as well as with bacterial antigens, the Clq reaction may in fact be detecting antigenemia in many instances. Considerable caution is warranted in application of sensitive screening tests for assay of circulating immune complexes in various states of infectious diseases.(AU). Descriptors: HANSENIASE/imunol TECNICAS IMUNOLOGICAS DNA/imunol DNA/metab ANTICORPOS COMPLEXO ANTIGENO-ANTICORPO LINHAGEM CELULAR COMPLEMENTO/metab COMPLEMENTO 1/metab LUPUS ERITEMATOSO SISTÊMICO/imunol Limits: ESTUDO COMPARATIVO HUMANO SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 01271/s

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Id: 12240 Author: Brahmbhatt, S; Hussain, R; Zafar, S; Dawood, G; Ottenhoff, T. H. M; Drijfhout, J. W; Bothamley, G; Smith, S; Lopez, F. V; Dockrell, H. M Title: Human T cell responses to peptides of the mycobacterium leprae 45-kD serine-rich antigen ..- Source: s.l; s.n; 2002. 9 p. tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS LINHAGEM CELULAR EPITOPOS DE LINFOCITO T EPITOPOS DE LINFOCITO T REINO UNIDO ANTIGENOS HLA-DR EPITOPOS IMUNODOMINANTES EPITOPOS IMUNODOMINANTES INTERFERON TIPO II HANSENIASE TUBERCULOIDE PAQUISTAO PEPTIDIOS HOMOLOGIA DE SEQUENCIA DE AMINOACIDOS SERINA LINFOCITOS T TUBERCULOSE PULMONAR Células Cultivadas Limits: ESTUDO COMPARATIVO Location: BR191.1; 08643/s

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Id: 11759 Author: Brahmbhatt, S; Hussain, R; Zafar, S; Dawood, G; Ottenhoff, Tom H. M; Drijfhout, J. W; Bothamley, G; Smith, S; Lopez, F. V; Dockrell, H. M Title: Human T cell responses to peptides of the Mycobacterium leprae 45-KD serine-rich antigen ..- Source: s.l; s.n; 2002. 9 p. tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS LINHAGEM CELULAR EPITOPOS DE LINFOCITO T EPITOPOS DE LINFOCITO T REINO UNIDO ANTIGENOS HLA-DR EPITOPOS IMUNODOMINANTES EPITOPOS IMUNODOMINANTES INTERFERON TIPO II HANSENIASE TUBERCULOIDE DADOS DE SEQUENCIA MOLECULAR PESO MOLECULAR MYCOBACTERIUM LEPRAE PAQUISTAO PEPTIDIOS HOMOLOGIA DE SEQUENCIA DE AMINOACIDOS SERINA LINFOCITOS T TUBERCULOSE PULMONAR CELULAS CULTIVADAS Limits: ESTUDO COMPARATIVO Location: BR191.1; 08519/s

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Id: 11651 Author: Nakanga, Kazue; Nomaguchi, Hiroko; Matsuoka, Masanori Title: Establishment of mouse cell lines expressing Micobacterium leprae 65KDa heat shock protein gene ..- Source: s.l; s.n; 1996. 8 p. graf. Descriptors: HANSENIASE MYCOBACTERIUM LEPRAE LINHAGEM CELULAR CHAPERONINAS CHAPERONINAS EXPRESSAO GENICA CAMUNDONGOS ENDOGAMICOS BALB C RNA MENSAGEIRO LINFOCITOS T CITOTOXICOS TRANSFECÇAO Location: BR191.1; 08462/s

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Id: 10166 Author: Struyk, Linda; Hawes, Gail E; Haanen, John B. A. G; Vries, Rene R. P. de; Van den Elsen, Peter J Title: Clonal dominance and selection for similar complementarity determining region 3 motifs among T lymphocytes responding to the HLA-DR3-associated Mycobacterium leprae shock protein 65-kd peptide 3-13 ..- Source: s.l; s.n; 1995. 8 p. ilus, tab. Descriptors: HANSENIASE TUBERCULOIDE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE LINFOCITOS T SEQUENCIA DE AMINOACIDOS PROTEINAS DE BACTÉRIAS SEQUENCIA DE BASES LINHAGEM CELULAR CHAPERONINAS CHAPERONINAS PRIMERS DO DNA ANTIGENO HLA-DR3 REGIAO VARIAVEL DE IMUNOGLOBULINA DADOS DE SEQUENCIA MOLECULAR FRAGMENTOS DE PEPTIDIOS FRAGMENTOS DE PEPTIDIOS RECEPTORES PARA ANTIGENOS DE CÉLULAS T ALFA-BETA Limits: HUMANO Location: BR191.1; 07079/s

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Id: 9799 Author: Sieling, P. A; Chatterjee, D; Porcelli, S. A; Prigozy, T. I; Mazzaccaro, R. J; Soriano, T; Bloom, B. R; Brenner, M. B; Kronenberg, M; Brennan, P. J; Modlin, R. L Title: CD1-restricted T cell recognition of microbial lipoglycan antigens ..- Source: s.l; s.n; 1995. 4 p. ilus, graf. Descriptors: MYCOBACTERIUM LEPRAE APRESENTAÇAO DO ANTIGENO CÉLULAS QUE APRESENTAM ANTIGENOS ANTIGENOS CD ANTIGENOS CD1 CONFIGURAÇAO DE CARBOIDRATOS SEQUENCIA DE CARBOIDRATOS LINHAGEM CELULAR INTERFERON TIPO II HANSENIASE LIPOPOLISSACARIDIOS TRANSFORMAÇAO LINFOCITICA DADOS DE SEQUENCIA MOLECULAR FOSFATIDILINOSITOIS RECEPTORES PARA ANTIGENOS DE CÉLULAS T ALFA-BETA ESPECIFICIDADE DE ESPÉCIES LINFOCITOS T CITOTOXICOS Location: BR191.1; 06749/s

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Id: 9671 Author: Sieling, Peter A; Abrams, John S; Yamamura, Masahiro; Salgame, Padmini; Bloom, Barry R; Rea, Thomas H; Modlin, Robert L Title: Immunosuppressive roles for Il-10 and IL-4 in human infection: in vitro modulation of T cell response in leprosy ..- Source: s.l; s.n; 1993. 10 p. ilus, tab, graf. Descriptors: LINHAGEM CELULAR FATOR ESTIMULADOR DE COLONIAS DE GRANULOCITOS-MACROFAGOS TOLERANCIA IMUNOLOGICA INTERFERON TIPO II INTERLEUCINA-10 INTERLEUCINA-4 HANSENIASE HANSENIASE HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE TRANSFORMAÇAO LINFOCITICA MYCOBACTERIUM LEPRAE LINFOCITOS T FATOR DE NECROSE TUMORAL/BI Location: BR191.1; 06679/s

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Id: 9640 Author: Byrd, Sally; Gelber, Robert; Bermudez, Luiz E Title: Roles of soluble fibronectin and B1 integrin receptors in the binding of Mycobacterium leprae to nasal epithelial cells ..- Source: s.l; s.n; 1993. 6 p. tab. Descriptors: HANSENIASE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE SEQUENCIA DE AMINOACIDOS PROTEINAS DE BACTÉRIAS LINHAGEM CELULAR EPITÉLIO FIBRONECTINAS INTEGRINAS LIGANTES MACROFAGOS SEPTO NASAL SEPTO NASAL OLIGOPEPTIDIOS ENSAIO RADIOLIGANTE LIGAÇAO PROTÉICA SOLUBILIDADE Location: BR191.1; 06552/s

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Id: 9415 Author: Uyemura, Koichi; Ho, Christopher T; Ohmen, Jeffrey D; Rea, Thomas H; Modlin, Robert L Title: Selective expansion of VS1 + T cells from leprosy skin lesions ..- Source: s.l; s.n; 1992. 5 p. ilus, tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS VACINAS BACTERIANAS SEQUENCIA DE BASES LINHAGEM CELULAR REORDENAMENTO GENICO DO LINFOCITO T TESTES INTRADÉRMICOS HANSENIASE TUBERCULOIDE DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM LEPRAE - FENOTIPO  RECEPTORES DE ANTIGENO DA CÉLULA-T  RECEPTORES DE ANTIGENO DA CÉLULA-T  PELE  LINFOCITOS T Location: BR191.1; 06387/s

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Id: 9331 Author: Barnes, Peter F; Grisso, Cara L; Abrams, John S; Brand, Hamid; Rea, Thomas H; Modlin, Robert L Title: yS T lymphocytes in human tuberculosis ..- Source: Chicago; s.n; 1992. 7 p. tab, graf. Descriptors: LINHAGEM CELULAR CITOCINAS HANSENIASE CONTAGEM DE LEUCOCITOS TRANSFORMAÇAO LINFOCITICA MYCOBACTERIUM TUBERCULOSIS LINFOCITOS T TESTE TUBERCULINICO TUBERCULOSE MILIAR TUBERCULOSE PLEURAL TUBERCULOSE PULMONAR Location: BR191.1; 06471/s

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